Water Solubility Of Daidzein And Amino Modified Beta Cyclodextrin

Daidzein, also known as a kind of important isoflavonoids, mainly in leguminous plants such as soybean and pueraria. Research shows that daidzein has important pharmacological effects, including anti thrombus formation, and atherosclerosis, antioxidant, anti diabetic bone protection and anti-tumor effects. At the same time, daidzein by metabolism for S-equol has estrogen like in the gut. However, daidzein has poor solubility, low stability and poor oral absorption, resulting in low bioavailability and low absorption in vivo, which greatly hinders the effective use of its pharmacological effects. Therefore, improving the water solubility of daidzein is of great significance for improving its bioavailability and developing its medicinal value.

Cyclodextrin has "taper shaped molecular structure within the hydrophobic and hydrophilic, with many organic / inorganic molecules through a variety of non covalent interactions, such as Fan Dehua force, hydrogen bond, hydrophobic interaction and the formation of water soluble subject object inclusion or assemble into supramolecular complex system. When cyclodextrins are used as supramolecular bodies for insoluble drugs or bioactive molecules, their solubility, stability and bioavailability can be greatly improved. It has been found that the water solubility of the modified cyclodextrin can be greatly improved by modifying the beta cyclodextrin with amino groups. In two kinds of amino modified cyclodextrin derivative (ACD), which is a mono-(6-amino-6-deoxy)-beta-cyclodextrin and mono-(6-ethanediamine-6-deoxy)-beta-cyclodextrin (ENCD) as the main body, and hydroxypropyl betacyclodextrin, sulfobutyl betacyclodextrin and beta cyclodextrin as contrast, solubilization of amino modified cyclodextrin has stronger of daidzein.

Polyethylene Polyamine Modified Beta Cyclodextrin
mono diethylenetriamine deoxy beta Cyclodextrin
mono triethylenetetraamine deoxy beta Cyclodextrin
mono tetraethylenepentamine deoxy beta Cyclodextrin

Mono-6-p-Toluenesulfonyl Beta Cyclodextrin
Mono Toluenesulfonyl Beta Cyclodextrin
Mono Toluenesulfonyl Beta Cyclodextrin CAS 67217-55-4

Mono-6-Ethanediamine-6-Deoxy Beta Cyclodextrin
Mono Ethanediamine Deoxy Beta Cyclodextrin
Mono Ethanediamine Beta Cyclodextrin CAS 67217-55-4

Mono-(6-(1,6-Hexamethylenediamine)-6-deoxy) Beta Cyclodextrin
Mono Hexamethylenediamine deoxy Beta Cyclodextrin
Mono Hexamethylenediamine Beta Cyclodextrin CAS 131991-61-2

Mono-6-Azido-6-Deoxy Beta Cyclodextrin
Mono Azido Deoxy Beta Cyclodextrin
Mono Azido Beta Cyclodextrin CAS 98169-85-8

Oligo Beta Cyclodextrin
Oligo Lactic Acid Beta Cyclodextrin
Oligo Beta Cyclodextrin CAS  98169-85-8

Scientific Research Special Cyclodextrin Reagent mainly including:

Amino Beta Cyclodextrin	mono-(6-amino-6-deoxy)-beta-cyclodextrin
	Heptakis(6-amino-6-deoxy)-beta-cyclodextrin
Mercapto Beta Alpha Gamma Cyclodextrin	mono-(6-Mercapto-6-deoxy)-beta-Cyclodextrin
	Heptakis-(6-Mercapto-6-deoxy)-beta-Cyclodextrin
	Hexakis-(6-Mercapto-6-deoxy)-alpha-Cyclodextrin
Iodo  Beta Alpha Gamma Cyclodextrin	Hexakis-(6-Iodo-6-Deoxy)-alpha-Cyclodextrin
	Heptakis(6-iodo-6-deoxy)-beta-cyclodextrin
	Octakis-(6-Iodo-6-Deoxy)-gamma-Cyclodextrin

 

Cyclodextrin Reagent Derivatives

Amino Beta Cyclodextrin,Cyclodextrin Reagent Derivatives,Oligo Beta Cyclodextrin,Mercapto Beta Alpha Gamma Cyclodextrin

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